| Date | Location | Result | |
| May 13, 2022 | Chillicothe, Ohio | College of Wooster 5, DePauw 3 | Box score |
| May 13, 2022 | Chillicothe, Ohio | DePauw 7, Wittenberg 2 | Box score |
| May 12, 2022 | Chillicothe, Ohio | Denison 10, DePauw 5 | Box score |
| 5/8/2022 | Meadville, PA | DePauw 14, Allegheny 5 | Box score |
| 5/8/2022 | Meadville, PA | DePauw 13, Allegheny 4 | Box score |
| 5/4/2022 | Greencastle, Ind. | DePauw 5, Wabash 4 | Box score |
| 5/4/2022 | Greencastle, Ind. | DePauw 6, Wabash 5 | Box score |
| 5/1/2022 | Greencastle, Ind. | DePauw 12, Ohio Wesleyan 10 | Box score |
| 5/1/2022 | Greencastle, Ind. | DePauw 3, Ohio Wesleyan 1 | Box score |
| 4/27/2022 | Anderson, Ind. | DePauw 11, Anderson (Ind.) 10 | Box score |
| 4/26/2022 | Terre Haute, Ind. | DePauw 12, Rose-Hulman 8 | Box score |
| 4/23/2022 | Greencastle, Ind. | DePauw 11, Hiram 0 | Box score |
| 4/23/2022 | Greencastle, Ind. | DePauw 16, Hiram 0 | Box score |
| 4/19/2022 | Springfield, OH | DePauw 4, Wittenberg 3 | Box score |
| 4/19/2022 | Springfield, OH | Wittenberg 11, DePauw 10 | Box score |
| 4/16/2022 | Greencastle, Ind. | Kenyon 4, DePauw 3 | Box score |
| 4/16/2022 | Greencastle, Ind. | Kenyon 12, DePauw 1 | Box score |
| 4/10/2022 | Greencastle, Ind. | DePauw 16, Oberlin 10 | Box score |
| 4/10/2022 | Greencastle, Ind. | DePauw 7, Oberlin 3 | Box score |
| 4/7/2022 | Granville, Ohio | Denison 12, DePauw 2 | Box score |
| 4/7/2022 | Granville, Ohio | Denison 13, DePauw 2 | Box score |
| Apr 02, 2022 | Wooster, Ohio | College of Wooster 13, DePauw 6 | Box score |
| Apr 02, 2022 | Wooster, Ohio | DePauw 12, College of Wooster 4 | Box score |
| Mar 30, 2022 | Richmond, Ind | DePauw 10, Earlham College 3 | Box score |
| Mar 29, 2022 | Jefferson City, TN | Carson-Newman 13, DePauw 3 | Box score |
| 3/27/2022 | Maryville, Tenn. | Maryville (Tenn.) 11, DePauw 10 | Box score |
| 3/26/2022 | Maryville, Tenn. | Maryville (Tenn.) 11, DePauw 9 | Box score |
| 3/26/2022 | Maryville, Tenn. | Maryville (Tenn.) 11, DePauw 10 | Box score |
| 3/21/2022 | Terre Haute, Ind. | DePauw 10, Rose-Hulman 5 | Box score |
| 3/20/2022 | Greencastle, Ind. | DePauw 11, Franklin 2 | Box score |
| 3/20/2022 | Greencastle, Ind. | Franklin 16, DePauw 14 | Box score |
| Mar 05, 2022 | Conway, Ark. | Hendrix 8, DePauw 6 | Box score |
| Mar 05, 2022 | Conway, Ark | DePauw 9, Hendrix 6 | Box score |
| Mar 04, 2022 | Conway, Ark. | Hendrix 14, DePauw 7 | Box score |
| 2/27/2022 | Westfield, Ind. | DePauw 10, Transylvania 4 | Box score |
| 2/26/2022 | Westfield, Ind. | Baldwin Wallace 9, DePauw 8 | Box score |
| Feb 20, 2022 | Carbondale, Ill. | DePauw 25, Blackburn 7 | Box score |
| Feb 20, 2022 | Carbondale, Ill. | DePauw 16, Wilmington 0 | Box score |
| Feb 19, 2022 | Carbondale, Ill. | North Central 6, DePauw 3 | Box score |